Tfeb and liver
Web10 Jun 2024 · The function of TFEB is regulated mainly by nuclear translocation (Puertollano et al, 2024; Di Malta et al, 2024). To understand the transcription activation mechanisms of intestinal autophagy/lipophagy genes by TFEB, we examined the effect of feeding on nuclear localization of TFEB in both liver and intestine. Web1 Jul 2016 · TFEB overexpression has also shown therapeutic effects in mouse models of α1-antitrypsin deficiency, the most common genetic cause of liver disease (Pastore et al., 2013). In this case as well, enhanced intracellular clearance represents the major therapeutic mechanism, as induction of autophagy by TFEB reduces the levels of α1-antitrypsin …
Tfeb and liver
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WebTrehalose, a disaccharide, activates TFEB and protects against diet-induced nonalcoholic fatty liver disease in mice. The aim of the present study was to investigate whether … Web23 Nov 2024 · TFEB overexpression in the liver prevents weight gain and associated metabolic syndrome in both diet-induced and genetic mouse models of obesity . TFEB, as a PGC-1α-dependent regulator of adipocyte browning, has …
Web12 Apr 2024 · 世界卫生组织（WHO）研究数据显示超过40%的肝脏疾病跟酒精滥用相关【1】。酒精性肝病（alcohol-associated liver disease, ALD）是由于长期过量饮酒导致的肝脏一系列慢性病变过程。ALD初期通常表现为酒精性脂肪肝，进而发展为以肝脏 ... Web15 May 2024 · This study was conducted to investigate the autophagic response of Sertoli cells (SCs) to acute ethanol toxicity using in vivo and in vitro models. Adult Wistar rats were intraperitoneally injected with either 5 g/kg ethanol or phosphate-buffered saline (for the control group) and sacrificed 0, 3, 6 and 24 h after injection. Compared to the control …
Web7 Apr 2024 · 溶酶体功能抑制剂或干扰tfeb表达显著抑制槲皮素对乙醇所致细胞损伤的保护作用。 综上所述，槲皮素协同激活自噬，通过恢复溶酶体功能减少外泌体释放，并进一步减轻乙醇诱导的肝损伤。 Web6 May 2024 · Owing to its ability to improve disease status in murine models, TFEB has attracted attention as a therapeutic target for diseases. In this review, we will present the …
Web14 Sep 2024 · Transcription factor EB (TFEB) is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), and fibroblast growth factor 21 (FGF21) exerts a …
ham and green bean soup crock potWeb21 Apr 2013 · Tcfeb expression was significantly induced in liver, muscle and kidney of mice subjected to 24 h of food deprivation ( Fig. 1a ). Similar results were observed in vivo using a heterozygous... burnet county 33rd district courtWeb18 May 2024 · To investigate whether TFEB plays a role in liver cell commitment, we generated CRISPR/Cas9 Tcfeb KO (TFEB KO) (Supplementary Fig. 2a) and TFEB … ham and green beans crock pot recipeWeb28 Oct 2024 · In this aggressive liver disease setting, loss of Flcn led to activation of transcription factors TFEB and TFE3 to promote autophagy, promoting the degradation of intracellular lipid stores ... burnet county adult probation burnet txWeb10 Feb 2024 · Protein levels of JMJD3, TFEB, ATG7, ULK1, LC3-II, and p-ERK, detected by IB of liver extracts (Fig. 9b) or IHC of liver sections (Fig. 9c), were decreased in the patients. burnet county adult probationWeb17 Feb 2024 · For example, TFEB activates autophagy to indirectly inhibit liver steatosis and against weight gain in obesity (Zhang Y. et al., 2024). TFEB also contributes to being a … burnet county 911 address applicationWeb23 Jul 2024 · Transcription factor EB (TFEB) is a master transcriptional regulator of lysosomal biogenesis and autophagy and, when activated, is effective against disorders of lipid metabolism. However, the role of TFEB in hepatic steatosis is not well understood. burnet county 911 address office